Chang-Rung Chen

ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity

Neru Munshi, Sébastien Jeay, Youzhi Li et al. · Molecular Cancer Therapeutics · 2010 · 319 citations

Antitumor Activity, Cell Death, Pharmacotherapy +18

Defective repression of c- <i>myc</i> in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

Chang-Rung Chen, Yibin Kang, Joan Massagué · Proceedings of the National Academy of Sciences · 2001 · 318 citations

Breast Oncology, Cell Proliferation, C-myc Promoter +20

DNA Gyrase and Topoisomerase IV on the Bacterial Chromosome: Quinolone-induced DNA Cleavage

Chang-Rung Chen, Muhammad Malik, M Snyder et al. · Journal of Molecular Biology · 1996 · 275 citations · Full text

A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases

Sudharshan Eathiraj, Rocio Palma, Marscha Hirschi et al. · Journal of Biological Chemistry · 2011 · 61 citations · Full text

Dual Induction of Apoptosis and Senescence in Cancer Cells by Chk2 Activation: Checkpoint Activation as a Strategy against Cancer

Chang-Rung Chen, Wenxian Wang, Harry A. Rogoff et al. · Cancer Research · 2005 · 49 citations

Chemoprevention Strategy, Apoptosis, Cell Death +16