Timothy Middleton

Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1

Timothy Middleton, Bill Sugden · Journal of Virology · 1994 · 129 citations · Full text

Chromatin, Viral Replication, Plasmid Dna Indicate +14

<i>In Vitro</i> and <i>In Vivo</i> Antiviral Activity and Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor ABT-450

Rakesh Tripathi, Daniel E. Cohen, I. Gaultier et al. · Antimicrobial Agents and Chemotherapy · 2014 · 116 citations · Full text

Cytochrome P450 3A4, Viral Hepatitis, Medicine +13

DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.

Wu‐Chou Su, Timothy Middleton, Bill Sugden et al. · Proceedings of the National Academy of Sciences · 1991 · 105 citations

Viral Replication, Viral Polymerase Mechanism, Immunology +17

Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System

Yupeng He, Martin King, Dale J. Kempf et al. · Antimicrobial Agents and Chemotherapy · 2007 · 99 citations

Viral Replication, Mutant Susceptibility, Immunology +17

EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication

Timothy Middleton, Bill Sugden · Journal of Virology · 1992 · 95 citations · Full text

Viral Replication, Molecular Virology, Initiator Element +14