Aqueous Phosphoric Acid as a Mild Reagent for Deprotection of <i>tert</i>-Butyl Carbamates, Esters, and Ethers

Bryan Li, Martin A. Berliner, Richard A. Buzon, +15

The Journal of Organic Chemistry

Mild ReagentEngineeringBiochemistryAqueous Phosphoric AcidCyclic Carbamate +10

Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole

Danny Lafrance, Paul Bowles, Kyle R. Leeman, +1

Organic Letters

Combinatorial ChemistryDerivative (Chemistry)EngineeringBiochemistryChemical Derivative +7

Mixture Component Prediction Using Iterative Optimization Technology (Calibration-Free/Minimum Approach)

Koji Muteki, Daniel O. Blackwood, Brent J. Maranzano, +4

Industrial & Engineering Chemistry Research

EngineeringMachine LearningIndustrial EngineeringLinear IotMixture Of Expert +18

Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group

Bryan Li, Raymond J. Bemish, Richard A. Buzon, +7

Tetrahedron Letters

Bioorganic ChemistryMild ReagentBiochemistryT-butoxycarbonyl GroupNatural Sciences +3

Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated S_NAr Coupling

Shengquan Duan, D.W. Place, Hahdi H. Perfect, +13

Organic Process Research & Development

Combinatorial ChemistryCross-coupling ReactionEngineeringProcess DevelopmentSnar Coupling +8

Palbociclib Commercial Manufacturing Process Development. Part II: Regioselective Heck Coupling with Polymorph Control for Processability

Mark T. Maloney, Brian P. Jones, Mark A. Olivier, +13

Organic Process Research & Development

Extractive Chelation StepEngineeringMechanical EngineeringProcess DevelopmentOrganic Chemistry +22

Development of a New Variant of the Migita Reaction for Carbon−Sulfur Bond Formation Used in the Manufacture of Tetrahydro-4-[3-[4-(2-methyl-1<i>H</i>-imidazol-1-yl)phenyl]thio]phenyl-2<i>H</i>-pyran-4-carboxamide

Timothy Norris, Kyle R. Leeman

Organic Process Research & Development

Diversity Oriented SynthesisCross-coupling ReactionEngineeringNatural SciencesNew Variant +13

Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2<i>H</i>-Pyranone

Robert A. Singer, John A. Ragan, Paul Bowles, +16

Organic Process Research & Development

Dieckmann Cyclizationβ-Hydroxy Alkynyl OxazolidinoneBiosynthesis6,6-Disubstituted 2Evans Aldol Reaction +12

Palbociclib Commercial Manufacturing Process Development. Part III. Deprotection Followed by Crystallization for API Particle Property Control

Brian P. Chekal, Jason Ewers, Steven M. Guinness, +12

Organic Process Research & Development

Combinatorial ChemistryPharmaceutical ScienceEngineeringPart IiiIndustrial Engineering +19

Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

Brian P. Chekal, David B. Damon, Danny Lafrance, +13

Organic Process Research & Development

EngineeringOrganic ChemistryChemistryPharmaceutical ChemistryMedicinal Chemistry +20