Matthew P. Epplin

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

Riley E. Perszyk, Brooke M. Katzman, Hirofumi Kusumoto et al. · eLife · 2018 · 44 citations · Full text

Neurotransmitter, Molecular Biology, Neurotransmission +19

Biased modulators of NMDA receptors control channel opening and ion selectivity

Riley E. Perszyk, Sharon A. Swanger, Chris Shelley et al. · Nature Chemical Biology · 2020 · 44 citations · Full text

Ion Selectivity, Channel Opening, Medicine +9

Negative allosteric modulation of GluN1/GluN3 NMDA receptors

Zongjian Zhu, Feng Yi, Matthew P. Epplin et al. · Neuropharmacology · 2020 · 36 citations · Full text

Negative Allosteric Modulation, G Protein-coupled Receptor, Medicine +4

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

Thomas M. Kaiser, Steven A. Kell, Hirofumi Kusumoto et al. · Molecular Pharmacology · 2017 · 19 citations · Full text

The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Modulators that Potentiates GluN2B-Containing<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptors

Katie L. Strong, Matthew P. Epplin, John Bacsa et al. · Journal of Medicinal Chemistry · 2017 · 18 citations · Full text