CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Aubin Moutal, Xiaofang Yang, Wennan Li, +14

Pain

Pain MedicinePathologyNeuropathic PainMolecular PainNf1 Pain +16

A porcine model of neurofibromatosis type 1 that mimics the human disease

Katherine A. White, Vicki J. Swier, Jacob T. Cain, +25

JCI Insight

PathologySocial SciencesNeuro-oncologyNeurobiology Of DiseaseNf1 Patients +20

Homology‐guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2‐derived peptides

Aubin Moutal, Wennan Li, Yue Wang, +11

British Journal of Pharmacology

Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs

Wennan Li, Xingjuan Chen, Ashley M. Riley, +10

Basic Research in Cardiology

Developing flame-retardant, antibacterial cotton fabric by incorporating a linear polysiloxane-based coating

Xin Jin, Wennan Li, Shihao Wang, +4

Industrial Crops and Products

Materials ScienceEngineeringFire RetardancyPolymer ScienceAntibacterial Cotton Fabric +3

CRMP2–Neurofibromin Interface Drives NF1-related Pain

Aubin Moutal, Li Sun, Xiaofang Yang, +4

Neuroscience

Pain SyndromePain DisordersMolecular NeuroscienceNeurophysiologyPain Medicine +11

(−)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels

Song Cai, Shreya S. Bellampalli, Jie Yu, +11

ACS Chemical Neuroscience

Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

Xingjuan Chen, Wennan Li, Ashley M. Riley, +4

Journal of Biological Chemistry

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Rajesh Khanna, Amol Patwardhan, Xiaofang Yang, +12

Journal of Pain

Acute PainPain MedicineOptogeneticsPain SyndromePain Management +14

Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries

Xingjuan Chen, Wennan Li, S. Christopher Hiett, +1

PLoS ONE

Cardiac MuscleBradykinin-dependent RelaxationsDecay RateCardiovascular FunctionCellular Physiology +16