De-Xuan Hu

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents

Xiaoru Zhang, Haowen Wang, Wen-Lin Tang et al. · Journal of Medicinal Chemistry · 2018 · 49 citations · Full text

Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene <i>c-myc</i> Expression

Guotao Kuang, Meiling Zhang, Shuangshuang Kang et al. · Journal of Medicinal Chemistry · 2020 · 29 citations

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

De-Xuan Hu, Wen-Lin Tang, Yu Zhang et al. · Journal of Medicinal Chemistry · 2021 · 26 citations · Full text

Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription

Bing Shu, Ping Zeng, Shuangshuang Kang et al. · Bioorganic Chemistry · 2018 · 25 citations

Transcriptional Regulation, Signal Transduction, Molecular Regulation +11

Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors

Bing Shu, Yu Qian, De-Xuan Hu et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 21 citations

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +10