Transient activation of <i>c-MYC</i> expression is critical for efficient platelet generation from human induced pluripotent stem cells

Naoya Takayama, Satoshi Nishimura, Sou Nakamura, +13

The Journal of Experimental Medicine

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

Sou Nakamura, Naoya Takayama, Shinji Hirata, +15

Cell stem cell

Regenerative MedicineThrombopoiesisInduced Pluripotent Stem CellBlood PlateletMedicine +7

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production

Yukitaka Ito, Sou Nakamura, Naoshi Sugimoto, +25

Cell

MechanobiologyThrombosisThrombopoiesisEngineeringBlood Platelet +7

Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell–derived megakaryocytes

Yosuke Nakagawa, Sou Nakamura, Masahiro Nakajima, +7

Experimental Hematology

Regenerative MedicineTissue EngineeringInduced Pluripotent Stem CellHuman Pluripotent StemEngineering +12

Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells

Sho-ichi Hirose, Naoya Takayama, Sou Nakamura, +13

Stem Cell Reports

iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study

Naoshi Sugimoto, Junya Kanda, Sou Nakamura, +23

Blood

EngineeringImmunologySmall GroupBiomedical EngineeringIpsc-derived Platelets +17

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, +14

Stem Cell Reports

Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling

Shinji Hirata, Naoya Takayama, Ryoko Jono-Ohnishi, +11

Journal of Clinical Investigation

Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets

Shinji Hirata, Daisuke Suzuki, Sou Nakamura, +6

Stem Cells Translational Medicine

De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome

Tsutomu Toki, Kenichi Yoshida, RuNan Wang, +36

The American Journal of Human Genetics

Genome InstabilityBone Marrow FailureGenetic DisorderInherited Bone-marrow-failure SyndromeHematology +4