Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

Paul Proost, Tamara Loos, Anneleen Mortier, +10

The Journal of Experimental Medicine

Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria

Evelina Vågesjö, Emelie Öhnstedt, Anneleen Mortier, +5

Proceedings of the National Academy of Sciences

Tissue EngineeringEngineeringMicrobial PathogensImmunologyWound Assessment +15

Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation

Tamara Loos, Anneleen Mortier, Mieke Gouwy, +5

Blood

Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration

Paul Proost, Anneleen Mortier, Tamara Loos, +8

Blood

Citrullination of CXCL12 Differentially Reduces CXCR4 and CXCR7 Binding with Loss of Inflammatory and Anti-HIV-1 Activity via CXCR4

Sofie Struyf, Sam Noppen, Tamara Loos, +10

The Journal of Immunology

Cxcr4 BindingPosttranslational Proteolytic ProcessingImmunologyImmune RegulationImmunotherapy +17

Differential Cytokine, Chemokine and Growth Factor Expression in Phenotypes of Chronic Lung Allograft Dysfunction

Stijn E. Verleden, David Ruttens, Robin Vos, +8

Transplantation

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74–103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice

Vincent Vanheule, Rik Janssens, Daiane Boff, +9

Journal of Biological Chemistry

InflammationAutoimmune DiseaseGranulocyteMedicineGouty Arthritis +7

Posttranslational Modification of the NH2-terminal Region of CXCL5 by Proteases or Peptidylarginine Deiminases (PAD) Differently Affects Its Biological Activity

Anneleen Mortier, Tamara Loos, Mieke Gouwy, +3

Journal of Biological Chemistry

Recognition Versus Adaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence

Benedetta Savino, Elena Monica Borroni, Nina Machado Torres, +6

Journal of Biological Chemistry

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

Rik Janssens, Anneleen Mortier, Daiane Boff, +14

Biochemical Pharmacology

InflammationCytokineMolecular ImmunologyChemokine BiologyEndothelial Cells +9