Kurt Von Figura

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

Life Sciences, Molecular Biology, Neuroscience +15

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Paul Säftig, Ernst B. Hunziker, Olaf Wehmeyer et al. · Proceedings of the National Academy of Sciences · 1998 · 910 citations

Medicine, Cell Biology, Molecular Biology +17

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

Yoshitaka Tanaka, Gundula Guhde, Anke Suter et al. · Nature · 2000 · 902 citations · Full text

Life Sciences, Biochemistry, Cell Biology +9

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Paul Säftig, Michal Hetman, Wolfgang W. Schmahl et al. · The EMBO Journal · 1995 · 442 citations · Full text

Medicine, Pathobiology, Pathology +17

Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy.

R Niehues, Martin Hasilik, Gordon Alton et al. · Journal of Clinical Investigation · 1998 · 428 citations · Full text

Life Sciences, Biochemistry, Pathobiology +11