MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis

Brock A. Humphries, Zhishan Wang, Aaron L. Oom, +5

Carcinogenesis

Breast OncologyMicrorna-200b TargetsMedicineTumor ImmunityCancer Cell Biology +13

Integrin α5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway

Yajuan Xiao, Yunfei Li, Hua Tao, +6

Cancer Letters

Breast OncologyEpigenetic RegulationMedicineStem CellsCancer Cell Biology +12

ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA

Brock A. Humphries, Zhishan Wang, Yunfei Li, +3

Cancer Research

Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer

Brock A. Humphries, Johanna M. Buschhaus, Yu‐Chih Chen, +13

Molecular Cancer Research

Breast OncologyMolecular BiologyCytoskeletonCancer BiologyCellular Physiology +22

Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis

Yu‐Chih Chen, Saswat Sahoo, Riley Brien, +7

The Analyst

Migratory CellsEngineeringTranscriptomics TechnologyCancer MetastasisCancer Biology +18

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

Brock A. Humphries, Alyssa C. Cutter, Johanna M. Buschhaus, +18

Breast Cancer Research

Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation

Zhishan Wang, Brock A. Humphries, Kazuya Kondo, +3

Toxicology and Applied Pharmacology

Histone ModificationsChromatinCell RegulationChromatin RemodelingMedicine +10

MicroRNA-200b Suppresses Arsenic-transformed Cell Migration by Targeting Protein Kinase Cα and Wnt5b-Protein Kinase Cα Positive Feedback Loop and Inhibiting Rac1 Activation

Zhishan Wang, Brock A. Humphries, Hua Xiao, +2

Journal of Biological Chemistry

EngineeringProtein Kinase CαCancer BiologyTumor BiologyPkcα Expression +21

Root-Localized Phytochrome Chromophore Synthesis Is Required for Photoregulation of Root Elongation and Impacts Root Sensitivity to Jasmonic Acid in Arabidopsis    

Stephanie E. Costigan, Sankalpi Warnasooriya, Brock A. Humphries, +1

PLANT PHYSIOLOGY

Integrin α9 depletion promotes β‐catenin degradation to suppress triple‐negative breast cancer tumor growth and metastasis

Zhishan Wang, Yunfei Li, Yajuan Xiao, +5

International Journal of Cancer

β‐Catenin DegradationBreast OncologyCancer BiologyMammary Gland DevelopmentTumor Biology +14