Issey Takehara

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

Issey Takehara, Takashi Yoshikado, Keiko Ishigame et al. · Pharmaceutical Research · 2018 · 88 citations

Oatp1b Inhibition, Pharmacological Study, Healthy Volunteers +7

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

Issey Takehara, Hanano Terashima, Takeshi Nakayama et al. · Pharmaceutical Research · 2017 · 72 citations

Biochemistry, Healthy Japanese Volunteers, Medicine +9

Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

Takeshi Miyake, Tadahaya Mizuno, Issey Takehara et al. · Drug Metabolism and Disposition · 2019 · 40 citations · Full text

386O Exploratory biomarker analysis of DESTINY-CRC01, a phase II, multicenter, open-label study of trastuzumab deruxtecan (T-DXd, DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC)

Salvatore Siena, Kanwal Raghav, Toshiki Masuishi et al. · Annals of Oncology · 2021 · 24 citations · Full text

Phase Ii, Medicine, Immunology +9

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Issey Takehara, Nobuaki Watanabe, Daiki Mori et al. · Journal of Pharmaceutical Sciences · 2019 · 21 citations

Plasma Concentrations, Hepatology, Bile Acid-o-sulfates +9