Keigo Kosaka

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 148 citations · Full text

Biochemistry, Medicine, Rational Drug Design +7

Synthetic Studies on Cephalotaxus Alkaloids. A synthesis of (.+-.)-Cephalotaxine.

Masazumi Ikeda, M. OKANO, Keigo Kosaka et al. · Chemical and Pharmaceutical Bulletin · 1993 · 43 citations · Full text

Natural Product Synthesis, Derivatives, Natural Sciences +12

Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene

Keigo Kosaka, Norifumi Sakai, Yuya Endo et al. · Drug Metabolism and Disposition · 2011 · 35 citations

Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays

Atsushi Iwamura, Masahito Ito, Hideaki Mitsui et al. · Toxicology in Vitro · 2015 · 30 citations

Toxicological Evaluation, Immunotoxicology, Medicine +9

Diels‐alder reaction of (<i>E</i>)‐4‐(2‐nitroethenyl)‐1<i>H</i>‐imidazoles and methyl (<i>E</i>)‐3‐(1‐imidazol‐4‐yl)propenoates

Keigo Kosaka, Kazumi Maruyama, Haruko Nakamura et al. · Journal of Heterocyclic Chemistry · 1991 · 13 citations

Abstract Diels‐alder Reaction, Engineering, Heterocyclic +8