Jianxin Feng

Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (<i>Sa</i>)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-6(7<i>H</i>)-yl)-<i>N</i>,<i>N</i>-dimethylacetamide (BMS-767778)

Pratik Devasthale, Ying Wang, Wei Wang et al. · Journal of Medicinal Chemistry · 2013 · 44 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Organic Chemistry +23

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3

Chunjian Liu, Prasada Rao Jalagam, Jianxin Feng et al. · Journal of Medicinal Chemistry · 2022 · 29 citations · Full text

Pharmaceutical Science, Glycobiology, Immunology +18

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT_2CReceptor Agonists

Joseph Carpenter, Ying Wang, Gang Wu et al. · Journal of Medicinal Chemistry · 2017 · 16 citations · Full text

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

John M. Fevig, Jianxin Feng, Karen A. Rossi et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 15 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +7