Sébastien R. G. Galan

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Tom H. Wright, Ben Bower, Justin M. Chalker et al. · Science · 2016 · 328 citations

Engineering, Biochemistry, Molecular Biology +13

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 83 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

Mark D. Andrews, Kerry af Forselles, Kevin Beaumont et al. · ACS Medicinal Chemistry Letters · 2015 · 80 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Kuan-Yu Lai, Sébastien R. G. Galan, Yibo Zeng et al. · Cell · 2021 · 59 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Longbin Liu, Michael E. Prime, Matt R. Lee et al. · Journal of Medicinal Chemistry · 2020 · 56 citations

Medicine, Neuroscience, Nuclear Medicine +17