James Hillier

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Yuguang Zhao, Jingshan Ren, James Hillier et al. · Journal of Medicinal Chemistry · 2020 · 41 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum

Yuguang Zhao, Jingshan Ren, James Hillier et al. · Journal of Pineal Research · 2019 · 28 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

William Mahy, Mikesh Patel, David Steadman et al. · Journal of Medicinal Chemistry · 2020 · 20 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

5-Phenyl-1,3,4-oxadiazol-2(3<i>H</i>)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

William Mahy, Nicky J. Willis, Yuguang Zhao et al. · Journal of Medicinal Chemistry · 2020 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Caffeine inhibits Notum activity by binding at the catalytic pocket

Yuguang Zhao, Jingshan Ren, James Hillier et al. · Communications Biology · 2020 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12