Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma

Briana N. James, Clément Oyeniran, Jamie Sturgill, +12

Journal of Allergy and Clinical Immunology

AsthmaInflammationAnti-inflammatoryAllergyMedicine +8

Immunosuppression after Sepsis: Systemic Inflammation and Sepsis Induce a Loss of Naïve T-Cells but No Enduring Cell-Autonomous Defects in T-Cell Function

Robby Markwart, Stephanie A. Condotta, Robert Pascal Requardt, +9

PLoS ONE

Modulating sphingosine 1‐phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis

Nasr Y. A. Hemdan, Cynthia Weigel, Christina‐Maria Reimann, +1

European Journal of Immunology

A new preclinical model of western diet‐induced progression of non‐alcoholic steatohepatitis to hepatocellular carcinoma

Christopher D. Green, Cynthia Weigel, Ryan D. R. Brown, +4

The FASEB Journal

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

Christopher D. Green, Cynthia Weigel, Clément Oyeniran, +7

Journal of Lipid Research

Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis

Katharina Geißler, Robby Markwart, Robert Pascal Requardt, +5

PLoS ONE

InflammationAutoimmune DiseaseT-regulatory CellMagnetic SelectionImmunology +12

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

Cynthia Weigel, Sören S. Hüttner, Kristin Ludwig, +11

EBioMedicine

Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation

Jason Newton, Elisa N.D. Palladino, Cynthia Weigel, +9

Journal of Biological Chemistry

PathologyLipid MovementAutophagyNpc1 MutantAtherosclerosis +15

Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

Jefri Jeya Paul, Cynthia Weigel, Tina Müller, +3

Cells

ImmunologyEc BarrierAlleviating Autonomous SecretionCellular PhysiologyInflammation +15

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking

Elisa N.D. Palladino, Tytus Bernaś, Christopher D. Green, +11

Proceedings of the National Academy of Sciences

Proteinlipid InteractionMembrane Contact SitesMolecular BiologyLipid MovementCellular Physiology +17