Jeff Finkelstein

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

Roxana E. Georgescu, Lance D. Langston, Nina Y. Yao et al. · Nature Structural & Molecular Biology · 2014 · 198 citations

Life Sciences, Biology, Molecular Biology +13

CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

Lance D. Langston, Dan Zhang, Olga Yurieva et al. · Proceedings of the National Academy of Sciences · 2014 · 176 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

Roxana E. Georgescu, Grant D. Schauer, Nina Y. Yao et al. · eLife · 2015 · 140 citations · Full text

Life Sciences, Biology, Molecular Biology +14

Assembly of a Chromosomal Replication Machine: Two DNA Polymerases, a Clamp Loader, and Sliding Clamps in One Holoenzyme Particle. I. ORGANIZATION OF THE CLAMP LOADER

René Onrust, Jeff Finkelstein, Vytautas Naktinis et al. · Journal of Biological Chemistry · 1995 · 133 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression

Nina Y. Yao, Roxana E. Georgescu, Jeff Finkelstein · Proceedings of the National Academy of Sciences · 2009 · 120 citations · Full text

Life Sciences, Biophysics, Molecular Biology +17