The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

Dug Keun Lee, Seok Hee Park, Youngsuk Yi, +8

Genes & Development

ImmunologyHepatitis BPathologyHepatitis B VirusCirrhosis +23

Jab1/CSN5, a Component of the COP9 Signalosome, Regulates Transforming Growth Factor β Signaling by Binding to Smad7 and Promoting Its Degradation

Byung-Chul Kim, Ho-Jae Lee, Seok Hee Park, +6

Molecular and Cellular Biology

ImmunologyMolecular BiologyCop9 SignalosomeTgf-beta ResistanceSignaling Pathway +14

Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines.

Isaac Yi Kim, Byung Chul Kim, Do Hwan Seong, +6

PubMed

Molecular PharmacologyOncologySelective Estrogen ReceptorMedicineHormonal Receptor +13

The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence

Dug Keun Lee, Byung-Chul Kim, Isaac Yi Kim, +3

Journal of Biological Chemistry

Hpv-associated CarcinogenesisImmunologyCancer BiologyTumor BiologyViral Oncology +14

Human T-cell Lymphotropic Virus Type 1 Tax Inhibits Transforming Growth Factor-β Signaling by Blocking the Association of Smad Proteins with Smad-binding Element

Dug Keun Lee, Byung-Chul Kim, John Brady, +2

Journal of Biological Chemistry

Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells

Isaac Yi Kim, Dong-Hyeon Lee, Dug Keun Lee, +4

Oncogene

UrologyBone Morphogenic ProteinGenitourinary CancerProstatic DiseaseMedicine +4

Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway.

Isaac Yi Kim, Do Hwan Seong, Byung-Chul Kim, +5

PubMed

Molecular PharmacologyAndrogen-independent PathwaySelective Estrogen ReceptorChemoprevention StrategyMedicine +13

Decreased expression of bone morphogenetic protein (BMP) receptor type II correlates with insensitivity to BMP-6 in human renal cell carcinoma cells.

Isaac Yi Kim, Dong‐Hyeon Lee, Dug Keun Lee, +6

PubMed

Restoration of Bone Morphogenetic Protein Receptor Type II Expression Leads to a Decreased Rate of Tumor Growth in Bladder Transitional Cell Carcinoma Cell Line TSU-Pr1

Isaac Yi Kim, Dong‐Hyeon Lee, Dug Keun Lee, +5

Cancer Research

UrologyEndocrine-related CancerBone Morphogenic ProteinGenitourinary CancerDecreased Rate +12

Induction of G2/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells

Wenhua Piao, Jeman Yoo, Dug Keun Lee, +2

Biochemical Pharmacology

Promyelocytic LeukemiaG2/m Phase ArrestMedicineApoptosisPharmacology +5