Christina M. Lucato

Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors

Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran et al. · JCI Insight · 2021 · 79 citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +17

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

Christina M. Lucato, Michelle L. Halls, Lisa M. Ooms et al. · Journal of Biological Chemistry · 2015 · 68 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Yong‐Gang Chang, Christopher J. Lupton, Charles Bayly-Jones et al. · Nature Structural & Molecular Biology · 2022 · 24 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1

Laura D’Andrea, Christina M. Lucato, Elsa A. Marquez et al. · Science Signaling · 2021 · 15 citations · Full text

Medicine, Molecular Biology, Oncology +15