Matthew C. Deen

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway

Yanping Zhu, Xiaoyang Shan, Farzaneh Safarpour et al. · ACS Chemical Neuroscience · 2018 · 64 citations · Full text

Mitophagy, Glycobiology, Neurochemical Biomarkers +20

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi et al. · Nature Communications · 2023 · 36 citations · Full text

A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells

Matthew C. Deen, Yanping Zhu, Christina Gros et al. · Proceedings of the National Academy of Sciences · 2022 · 31 citations · Full text

Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates

Samy Cecioni, Roger A. Ashmus, Pierre‐André Gilormini et al. · Nature Chemical Biology · 2022 · 30 citations

Biosynthesis, Cellular Enzymology, Biochemistry +8

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High‐Throughput Screening: Application to <i>O</i>‐GlcNAc Transferase

Matthew G. Alteen, Christina Gros, Richard W. Meek et al. · Angewandte Chemie International Edition · 2020 · 26 citations