Eva Prchalová

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone, Liang Zhao, Judson M. Englert et al. · Science · 2019 · 1.1K citations

Immunology, Metabolic Remodeling, Immunotherapy +16

<i>N</i>-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-<scp>l</scp>-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

Michael T. Nedelcovych, Lukáš Tenora, Boe-Hyun Kim et al. · Journal of Medicinal Chemistry · 2017 · 65 citations · Full text

Aberrant Excitatory Neurotransmission, Neuropsychology, Psychopharmacology +23

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

Xiaolei Zhu, Michael T. Nedelcovych, Ajit G. Thomas et al. · Neuropsychopharmacology · 2018 · 53 citations · Full text

Psychoneuroimmunology, Psychiatry, Medicine +13

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders

Michael T. Nedelcovych, Boe-Hyun Kim, Xiaolei Zhu et al. · Journal of Neuroimmune Pharmacology · 2019 · 41 citations · Full text

Neuropsychology, Psychiatry, Neurovirology +12

N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs

Sarah C. Zimmermann, Tomáš Tichý, Jan Vávra et al. · Journal of Medicinal Chemistry · 2018 · 39 citations