Rishi R. Shah

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening

Christopher R. Wellaway, Dominique Amans, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2020 · 69 citations · Full text

Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs

Rishi R. Shah, Joanna M. Redmond, Andrei Mihut et al. · Bioorganic & Medicinal Chemistry · 2020 · 66 citations · Full text

Protein Chemistry, Engineering, Biochemistry +10

Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs

Rishi R. Shah, Elena De Vita, Preethi S. Sathyamurthi et al. · Journal of Medicinal Chemistry · 2024 · 32 citations · Full text

Combinatorial Chemistry, Supramolecular Assembly, Engineering +22

Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432

P. G. Humphreys, Niall A. Anderson, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2022 · 16 citations · Full text

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2021 · 14 citations · Full text

Asthma, Lung Delivery, Drug Target +22