Patrick van Eijk

Negative DNA supercoiling induces genome-wide Cas9 off-target activity

Matthew D. Newton, Marialucrezia Losito, Quentin M. Smith et al. · Molecular Cell · 2023 · 40 citations · Full text

Chromatin, Gene Therapies, Transcriptional Regulation +14

Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin

Shirong Yu, Katie Evans, Patrick van Eijk et al. · Genome Research · 2016 · 35 citations · Full text

Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq

Felix Dobbs, Patrick van Eijk, Mick D. Fellows et al. · Nature Communications · 2022 · 35 citations · Full text

DNA replication initiation shapes the mutational landscape and expression of the human genome

Pierre Murat, Consuelo Perez, Alastair Crisp et al. · Science Advances · 2022 · 33 citations · Full text

Genetics, Genomic Mechanism, Molecular Biology +17

The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4

Ben den Dulk, Patrick van Eijk, M. de Ruijter et al. · DNA repair · 2008 · 26 citations

Protein Function, Molecular Regulation, Natural Sciences +9