Philip M. Leonard

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Roland W. Bürli, Christopher A. Luckhurst, Omar Aziz et al. · Journal of Medicinal Chemistry · 2013 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Crystal structure of the Lrp‐like transcriptional regulator from the archaeon Pyrococcus furiosus

Philip M. Leonard · The EMBO Journal · 2001 · 149 citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Highly Potent First Examples of Dual Aromatase−Steroid Sulfatase Inhibitors based on a Biphenyl Template

L. W. Lawrence Woo, Toby Jackson, Aurélien Putey et al. · Journal of Medicinal Chemistry · 2010 · 80 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis

F. Brebion, Romain Gosmini, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2021 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors

Christopher A. Luckhurst, Perla Breccia, Andrew J. Stott et al. · ACS Medicinal Chemistry Letters · 2015 · 55 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10