Andrew Bowie

IFI16 is an innate immune sensor for intracellular DNA

Leonie Unterholzner, Sinéad E. Keating, Marcin Baran et al. · Nature Immunology · 2010 · 1.6K citations · Full text

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott, Andrew Bowie et al. · Nature · 2001 · 1.3K citations

Toll-like Receptors, Immunogenetics, Molecular Immunology +5

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Gillian Dunphy, Sinéad Flannery, Jessica F. Almine et al. · Molecular Cell · 2018 · 621 citations · Full text

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Elizabeth C. Carroll, Lei Jin, Andrés Mori et al. · Immunity · 2016 · 560 citations · Full text

Vaccination, Mucosal Vaccination, Vaccine Development +7

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Tengchuan Jin, Andrew Perry, Jiansheng Jiang et al. · Immunity · 2012 · 547 citations · Full text

Aim2 Inflammasome, Signal Transduction, Receptor (Biochemistry) +9