Sergio E. Alvarez

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Sergio E. Alvarez, Kuzhuvelil B. Harikumar, Nitai C. Hait et al. · Nature · 2010 · 735 citations · Full text

Missing Cofactor, Protein Function, Signal Transduction +7

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal

David Gude, Sergio E. Alvarez, Steven W. Paugh et al. · The FASEB Journal · 2008 · 348 citations · Full text

Chemoprevention Strategy, Apoptosis, Immunology +20

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

Megan M. Price, Carole A. Oskeritzian, Yves T. Falanga et al. · Journal of Allergy and Clinical Immunology · 2012 · 145 citations · Full text

Inflammation, Asthma, Signal Transduction +12

The S1P₂ Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation

Sravan K. Goparaju, Puneet S. Jolly, Kenneth R. Watterson et al. · Molecular and Cellular Biology · 2005 · 131 citations · Full text

Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

Dai Shida, Xianjun Fang, Tomasz Kordula et al. · Cancer Research · 2008 · 128 citations · Full text