Małgorzata Sierant

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Sherry Y. Wu, Xianbin Yang, Kshipra M. Gharpure et al. · Nature Communications · 2014 · 132 citations · Full text

Medicinal Chemistry, Drug Targeting, Biochemistry +10

Evoking picomolar binding in RNA by a single phosphorodithioate linkage

Nalin Abeydeera, Martin Egli, Nehemiah Cox et al. · Nucleic Acids Research · 2016 · 119 citations · Full text

Rna Aptamers, Molecular Biology, Molecular Genetics +23

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

Masayuki Sano, Małgorzata Sierant, Makoto Miyagishi et al. · Nucleic Acids Research · 2008 · 112 citations · Full text

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

Rafał Dolot, Curtis H. Lam, Małgorzata Sierant et al. · Nucleic Acids Research · 2018 · 71 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, Protein Assembly +19

Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions

Xianbin Yang, Małgorzata Sierant, Magdalena Janicka et al. · ACS Chemical Biology · 2012 · 59 citations · Full text