Iris Ruf

Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels

Anna Lisa Gündner, Gonzalo Durán-Pacheco, Silke Zimmermann et al. · Neurobiology of Disease · 2018 · 66 citations · Full text

Neurodegenerative Diseases, α-Synuclein Levels, Disease Mechanism +7

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Ming Jiang, Mirjam Huizenga, Jonah L. Wirt et al. · Nature Communications · 2023 · 45 citations · Full text

Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

Leona Ho, Anja Osterwald, Iris Ruf et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2019 · 42 citations · Full text

Inflammation, Fibrogenic Activity, Ophthalmology +9

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi et al. · Nature Communications · 2023 · 36 citations · Full text

Metabolite Identification via LC‐SPE‐NMR‐MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

Simona Ceccarelli, Götz Schlotterbeck, Patrick Boissin et al. · ChemMedChem · 2007 · 22 citations

Lead Compounds, Metabolomic Profiling, Lead Identification +18