Sumitsugu Kisanuki

Kynostatin (KNI-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine.

Tsutomu Mimoto, Junya Imai, Sumitsugu Kisanuki et al. · Chemical and Pharmaceutical Bulletin · 1992 · 147 citations · Full text

Bioorganic Chemistry, Transition-state Mimic, Tripeptide Derivatives +17

KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic.

Tsutomu Mimoto, Naoko Hattori, Sumitsugu Kisanuki et al. · Chemical and Pharmaceutical Bulletin · 1991 · 81 citations · Full text

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.

Tsutomu Mimoto, Junya Imai, Shigeki Tanaka et al. · Chemical and Pharmaceutical Bulletin · 1991 · 75 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Antiviral Compound +15

Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere.

Tsutomu Mimoto, Naoko Hattori, Haruo Takaku et al. · Chemical and Pharmaceutical Bulletin · 2000 · 45 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Antiviral Drug +16

Comparison of a new orally potent tripeptide HIV‐1 protease inhibitor (anti‐aids drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations

Akiko Kiriyama, Tsutomu Mimoto, Sumitsugu Kisanuki et al. · Biopharmaceutics & Drug Disposition · 1993 · 15 citations

Immunology, Pharmacotherapy, Antiviral Drug +20