Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

Lie Wang, Kathryn F. Wildt, Jinfang Zhu, +6

Nature Immunology

Transcription Factors Gata-3Signal TransductionIntrathymic DifferentiationLymphocyte DevelopmentT-regulatory Cell +8

The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4+ T Cells

Lie Wang, Kathryn F. Wildt, Ehydel Castro, +4

Immunity

Systems BiologyT-regulatory CellGene ExpressionTranscription RegulationCell Biology

Themis, a T cell–specific protein important for late thymocyte development

Renaud Lesourne, Shoji Uehara, Jan Lee, +9

Nature Immunology

Developmental BiologyLymphocyte DevelopmentImmune Cell DevelopmentCell SignalingT Cell–specific Protein +8

HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4⁺T cells

Claudia Cicala, James Arthos, A. Rubbert, +4

Proceedings of the National Academy of Sciences

Induction of Phosphorylation and Intracellular Association of CC Chemokine Receptor 5 and Focal Adhesion Kinase in Primary Human CD4+ T Cells by Macrophage-Tropic HIV Envelope

Claudia Cicala, James Arthos, Margaret Ruiz, +6

The Journal of Immunology

Chemokine BiologyImmunologyImmunologic MechanismCd4 T Cell ResponsesImmunotherapy +15

The Transcription Factor Zbtb7b Promotes CD4 Expression by Antagonizing Runx-Mediated Activation of the CD4 Silencer

Kathryn F. Wildt, Guangping Sun, Baerbel Grueter, +4

The Journal of Immunology

The transcription factor Ets1 is important for CD4 repression and <i>Runx3</i> up-regulation during CD8 T cell differentiation in the thymus

Mónica Zamisch, Linhua Tian, Roland Grenningloh, +5

The Journal of Experimental Medicine

Lymphocyte DevelopmentAdaptive Immune SystemImmune RegulationImmunologyCd4 T Cell Responses +19

Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity

Sophia D. Sarafova, Batu Erman, Qing Yu, +7

Immunity

Transcriptional RegulationCoreceptor TranscriptionDevelopmental BiologySignal TransductionGenetics +6

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d‐restricted CD4⁺ NKT cells

Lie Wang, Tiffany Carr, Yumei Xiong, +5

European Journal of Immunology

Signal TransductionLymphocyte DevelopmentImmune Cell DevelopmentT-regulatory CellImmune Regulation +13

Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.

Oren J. Cohen, Mauro Vaccarezza, Gregory K.W. Lam, +22

Journal of Clinical Investigation

ImmunologyPathologyDefective GeneVirologic PhenotypeHiv-infected Long-term Nonprogressors +14