A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

Dipanjan Chowdhury, Xingzhi Xu, Xueyan Zhong, +7

Molecular Cell

Molecular RegulationNatural SciencesDna ReplicationMolecular BiologyCellular Biochemistry +1

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates γ-H2AX

Pauline Douglas, Jianing Zhong, Ruiqiong Ye, +3

Molecular and Cellular Biology

Dna DamageMolecular RegulationMolecular BiologyProtein Phosphatase 6Cell Regulation +14

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Jingjing Duan, Jian Li, Gui-Lan Chen, +19

Science Advances

OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers

Tao Wang, Shasha Ruan, Xiaolu Zhao, +7

Nucleic Acids Research

EngineeringGeneticsPathologyOncogenic Driver VariantsTumor Biology +15

Artesunate-induced mitophagy alters cellular redox status

Jianbin Zhang, Xin Sun, Liming Wang, +10

Redox Biology

MitophagyCell DeathMitochondrial FunctionsMitochondrial FissionRedox Biology +14

TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function

Jianing Zhong, Xianfeng Li, Wanshi Cai, +11

Nucleic Acids Research

Histone ModificationsMolecular RegulationDna Demethylation ActivityGeneticsDna Methylation +20

Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks

Jianing Zhong, Ji Liao, Xin Liu, +10

Cell Cycle

Dna Double-strand BreaksMolecular BiologyProtein Phosphatase Pp6Tumor BiologyCancer Cell Biology +15

Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks

Jinping Liu, Linli Xu, Jianing Zhong, +3

Cell Cycle

ChromatinGenome InstabilityProtein FunctionDna Double-strand BreaksBiochemistry +13

OncoBase: a platform for decoding regulatory somatic mutations in human cancers

Xianfeng Li, Leisheng Shi, Yan Wang, +10

Nucleic Acids Research

EngineeringGeneticsMolecular BiologyEpigeneticsTumor Biology +21

Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice

Bingxin Lu, Jianing Zhong, Jianfei Pan, +7

Journal of Translational Medicine