Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Jigang Wang, Chong‐Jing Zhang, Wan Ni Chia, +17

Nature Communications

Bioorganic ChemistryAntiparasitic AgentMalariaMolecular BiologyPlasmodium Falciparum +15

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

Jing Zhou, Shi-Hao Tan, Valérie Nicolas, +6

Cell Research

Cell AutophagyMitophagySignal TransductionMtorc1 SuppressionAutophagosome-lysosome Fusion +10

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

Jianbin Zhang, Shukie Ng, Jigang Wang, +6

Autophagy

MitophagyAutophagy InhibitorsCell DeathEpigeneticsCell Autophagy +14

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

Liming Wang, Yik-Lam Cho, Yancheng Tang, +25

Cell Research

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

Jianbin Zhang, Jigang Wang, Jian Xu, +5

Oncotarget

MitophagyChemoprevention StrategyImmunologyCell DeathCell Autophagy +15

Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors

Jianbin Zhang, Jigang Wang, Zhihong Zhou, +10

Autophagy

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

Jigang Wang, Jianbin Zhang, Yin Shi, +11

ACS Central Science

BiochemistryOncogenic AgentMedicineHerb-drug InteractionCell Death +12

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

Jigang Wang, Xing Fei Tan, Văn Sáng Nguyễn, +15

Molecular & Cellular Proteomics

Drug TargetChemoprevention StrategyCancer BiologyTumor BiologySystems Pharmacology +23

Mechanism‐Guided Design and Synthesis of a Mitochondria‐Targeting Artemisinin Analogue with Enhanced Anticancer Activity

Chong‐Jing Zhang, Jigang Wang, Jianbin Zhang, +6

Angewandte Chemie International Edition

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

Jigang Wang, Jianbin Zhang, Chong‐Jing Zhang, +7

Scientific Reports

Systems BiologyAffinity EnrichmentCurcumin TargetsChemoprevention StrategyMedicine +13