Patrick V. Holec

Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez et al. · Nature Biomedical Engineering · 2022 · 64 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains

Daniel Woldring, Patrick V. Holec, Hong Zhou et al. · PLoS ONE · 2015 · 56 citations · Full text

Life Sciences, Evolutionary Biology, Molecular Biology +17

A Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold

Daniel Woldring, Patrick V. Holec, Lawrence A. Stern et al. · Biochemistry · 2017 · 46 citations

Pharmacy, Biology, Medicinal Chemistry +17

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Yi‐Gen Pan, Benjamas Aiamkitsumrit, Laurent Bartolo et al. · Immunity · 2021 · 27 citations · Full text

Life Sciences, Immunology, Infectious Diseases +14

Biophysical Characterization Platform Informs Protein Scaffold Evolvability

Alexander W. Golinski, Patrick V. Holec, Katelynn M. Mischler et al. · ACS Combinatorial Science · 2019 · 21 citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16