Naofumi Seira

Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells

Kenji Yoshida, Hiromichi Fujino, Sho Otake et al. · European Journal of Pharmacology · 2013 · 28 citations

Life Sciences, Cell Biology, Pharmacology +10

Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells

Hiromichi Fujino, Naofumi Seira, Naoki Kurata et al. · European Journal of Pharmacology · 2015 · 15 citations

Life Sciences, Biochemistry, Pharmacology +13

PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells

Masato Mashimo, Asuka Shimizu, Aimi Mori et al. · Biochemical and Biophysical Research Communications · 2022 · 14 citations

Medicine, Molecular Biology, Oncology +9

Cellular density‐dependent down‐regulation of <scp>EP</scp>4 prostanoid receptors via the up‐regulation of hypoxia‐inducible factor‐1<i>α</i> in <scp>HCA</scp>‐7 human colon cancer cells

Sho Otake, Kenji Yoshida, Naofumi Seira et al. · Pharmacology Research & Perspectives · 2014 · 11 citations · Full text

Medicine, Molecular Biology, Oncology +14

Cellular density‐dependent increases in <scp>HIF</scp>‐1α compete with c‐Myc to down‐regulate human <scp>EP</scp>4 receptor promoter activity through Sp‐1‐binding region

Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima et al. · Pharmacology Research & Perspectives · 2018 · 10 citations · Full text

Medicine, Molecular Biology, Oncology +15