Chiara Rotolo

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Chiara Brullo, Roberta Ricciarelli, Jos Prickaerts et al. · European Journal of Medicinal Chemistry · 2016 · 38 citations

Medicinal Chemistry, Alzheimer's Disease, Structural Development +11

Homology Modeling, Docking Studies and Molecular Dynamic Simulations Using Graphical Processing Unit Architecture to Probe the Type‐11 Phosphodiesterase Catalytic Site: A Computational Approach for the Rational Design of Selective Inhibitors

Elena Cichero, Pasqualina D’Ursi, Marco Moscatelli et al. · Chemical Biology & Drug Design · 2013 · 27 citations

Drug Target, Pde11 X-ray Structures, Engineering +23

Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde <i>O</i>-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors

Chiara Brullo, Matteo Massa, Massimo Rocca et al. · Journal of Medicinal Chemistry · 2014 · 19 citations · Full text

Drug Target, New Series, Chemical Biology +19

One‐Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives

Matteo Lusardi, Chiara Rotolo, Marco Ponassi et al. · ChemMedChem · 2022 · 16 citations · Full text

Chemoprevention Strategy, Organic Chemistry, Prepared Compounds +18

Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents

Andrea Spallarossa, Chiara Rotolo, Claudia Sissi et al. · Bioorganic & Medicinal Chemistry · 2013 · 11 citations · Full text

Potent Antiproliferative Agents, Medicinal Chemistry, Pharmaceutical Science +10