Shalenie P. den Braver-Sewradj

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Nico Vermeulen et al. · Toxicology in Vitro · 2016 · 49 citations

Hepatology, Biochemistry, Medicine +12

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines

Michiel W. den Braver, Shalenie P. den Braver-Sewradj, Nico Vermeulen et al. · Toxicology Letters · 2016 · 32 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +14

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Robin M. Toorneman et al. · Chemical Research in Toxicology · 2017 · 20 citations · Full text

Quinone Oxidoreductase 1, Metabolomic Profiling, Redox Biology +21

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals

Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Marc van Dijk et al. · Current Drug Metabolism · 2018 · 17 citations · Full text

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

Yongjie Zhang, Shalenie P. den Braver-Sewradj, J. Chris Vos et al. · Toxicology Letters · 2017 · 12 citations · Full text

Reactive Quinoneimines, Amodiaquine-induced Liver Toxicity, Aldehyde Dehydrogenase +14