Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

Suphansa Sawamiphak, Sascha Seidel, Clara L. Essmann, +4

Nature

Developmental BiologyAngiogenesisTumour AngiogenesisVascular BiologyMedicine +2

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

Sascha Seidel, Boyan K. Garvalov, Valtteri Wirta, +11

Brain

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

Chenchen Pan, Oliver Schoppe, Arnaldo Parra‐Damas, +24

Cell

Deep LearningMedicineImmunologyComputational PathologyEntire Body +6

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

Marco Reis, Cathrin J. Czupalla, Nicole Ziegler, +12

The Journal of Experimental Medicine

GliomaTumor BiologyPdgf-b ExpressionNeuro-oncologyAngiogenesis +18

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

Alina Filatova, Sascha Seidel, Nuray Böğürcü, +3

Cancer Research

Tumor BiologyTumor AcidificationHif FunctionHypoxia-inducible FactorsCell Regulation +13

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

Cornelia Depner, H. zum Buttel, Nuray Böğürcü, +13

Nature Communications

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Anne‐Theres Henze, Boyan K. Garvalov, Sascha Seidel, +11

Nature Communications

PHD3 regulates EGFR internalization and signalling in tumours

Boyan K. Garvalov, Franziska Foss, Anne‐Theres Henze, +9

Nature Communications

Signaling PathwayPhd3 InactivationEgfr InternalizationCell SignalingProlyl Hydroxylase Phd3 +10

Isolation and Culture of Primary Glioblastoma Cells from Human Tumor Specimens

Sascha Seidel, Boyan K. Garvalov, Till Acker

Methods in molecular biology

Primary Glioblastoma CellsTumoral PathologyGliomaPathologyCell Culture +6

Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts

Nuray Böğürcü, Sascha Seidel, Boyan K. Garvalov, +1

Methods in molecular biology