Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Yong Xiong, Yuan Liu, Liu Cao, +16

Emerging Microbes & Infections

InflammationCytokineLong CovidViral DiagnosticsRespiratory Diseases +13

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Yingjun Li, Liu Cao, Ge Li, +13

Journal of Medicinal Chemistry

ImmunologyAntiviral DrugViral Structural ProteinCovid-19Antiviral Drug Development +14

Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

Anthony D. Saleh, Jason E. Savage, Liu Cao, +6

PLoS ONE

Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients

Yong Xiong, Yuan Liu, Liu Cao, +12

SSRN Electronic Journal

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

Ruangang Pan, Eveline Kindler, Liu Cao, +10

mBio

Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases

Panpan Hou, Yuxin Lin, Zibo Li, +10

Cellular and Molecular Immunology

InflammationAutophagy Receptor Ccdc50Autoimmune DiseaseImmunologyAntiviral Response +6

Solid tumor therapy by selectively targeting stromal endothelial cells

Shihui Liu, Jie Liu, Qian Ma, +6

Proceedings of the National Academy of Sciences

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

Lihong Liu, Jie Du, Sidi Yang, +12

Redox Biology

The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

Liu Cao, Yingjun Li, Sidi Yang, +37

Science Translational Medicine

Antiviral CompoundPharmacologyImmunologyPreclinical EfficacyVirology +10

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

Yunyun Jin, Hanwen Lin, Liu Cao, +12

Virologica Sinica

Biosafe RepliconAntiviral Drug DiscoveryViral EvolutionAccessory GenesAntiviral Drug Development +6