Effects of the novel (Pro3)GIP antagonist and exendin(9–39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

Victor A. Gault, Finbarr O’Harte, Patrick Harriott, +3

Diabetologia

Metabolic SyndromeInsulin SignalingBiochemistryMedicineInsulin Management +12

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

BD Green, MH Mooney, Nigel Irwin, +3

Journal of Endocrinology

Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide

Finbarr O’Harte, MH Mooney

Journal of Endocrinology

Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide

Patrick Harriott, MH Mooney, Finbarr O’Harte

Journal of Endocrinology

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo

BD Green, MH Mooney, Nigel Irwin, +3

Journal of Molecular Endocrinology

Glucose-lowering ActionGlycobiologyBiological ActivitiesInsulin SignalingGastrointestinal Peptide Hormone +18

Lys9 for Glu9 substitution in glucagon-like peptide-1(7–36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9–36)amide and exendin (9–39)

BD Green, MH Mooney, Victor A. Gault, +6

Metabolism

Molecular PharmacologyBiochemistryNatural SciencesMedicinePeptide Library +8

Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation.

Finbarr O’Harte, MH Mooney, Catherine M. Kelly, +1

Diabetes

Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay

JR Lindsay, Aine McKillop, MH Mooney, +3

Diabetologia

Insulin ResistanceMetabolic SyndromeHealth SciencesPhysiologyDiabetes +8

Degradation and glycemic effects of His7-glucitol glucagon-like peptide-1(7–36)amide in obese diabetic ob/ob mice

Finbarr O’Harte, MH Mooney, C.M.N Kelly, +2

Regulatory Peptides

Metabolic SyndromeInsulin SignalingBiochemistryMedicineDiabetes +8

Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues

AM McKillop, JT McCluskey, AC Boyd, +2

Journal of Endocrinology