Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor α in Mouse Liver Reveals Extensive Sharing of Binding Sites

Michael Boergesen, Thomas Åskov Pedersen, Barbara Gross, +11

Molecular and Cellular Biology

Sequential ChipGeneticsFatty Liver DiseaseLiver X ReceptorMetabolic Syndrome +23

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

Michał Pawlak, Eric Baugé, William Bourguet, +6

Hepatology

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

Philippe Lefèbvre, Fanny Lalloyer, Eric Baugé, +21

JCI Insight

GeneticsImmune RegulationImmunologyPathologyDermatopontin Expression +28

Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets

Fanny Lalloyer, B. Vandewalle, Frédéric Percevault, +9

Diabetes

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

Valeria Spinelli, Fanny Lalloyer, Grégory Baud, +14

International Journal of Obesity

Biliary TractRoux-en-y Gastric BypassPhysiologyGastroenterologyGastric Bypass +5

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, +27

Journal of Hepatology

InflammationHepatic PparαMolecular PhysiologyHepatologyDisease Pathophysiology +9

Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver

Fanny Lalloyer, Thomas Åskov Pedersen, Barbara Gross, +7

Arteriosclerosis Thrombosis and Vascular Biology

The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia

Fanny Lalloyer, Catherine Fiévet, Sophie Lestavel, +9

Arteriosclerosis Thrombosis and Vascular Biology

Peroxisome Proliferator–Activated Receptor-α Gene Level Differently Affects Lipid Metabolism and Inflammation in Apolipoprotein E2 Knock-In Mice

Fanny Lalloyer, Kristiaan Wouters, Morgane Baron, +8

Arteriosclerosis Thrombosis and Vascular Biology

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Marie Bobowski, Clémence Boulet, Francesco Paolo Zummo, +35

Nature Communications