Leslie Lupien

Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1

Benjamin Moyer, Itzel Y. Rojas, Joanna S. Kerley-Hamilton et al. · Toxicology and Applied Pharmacology · 2016 · 124 citations

Life Sciences, Biochemistry, Pharmacology +10

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Prasidda Khadka, Zachary J. Reitman, Sophie D. Lu et al. · Nature Communications · 2022 · 58 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

Leslie Lupien, Katarzyna Bloch, Jonas Dehairs et al. · Journal of Lipid Research · 2019 · 45 citations · Full text

Life Sciences, Cell Biology, Oncology +17

An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma

Leslie Lupien, Evan M. Dunkley, Margaret J. Maloy et al. · Journal of Pharmacology and Experimental Therapeutics · 2019 · 31 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +17