Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, +303

Science

Viral DiagnosticsCovid-19 PandemicViral PathogenesisImmunologyMolecular Biology +10

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Michael Schoof, Bryan Faust, Reuben A. Saunders, +143

Science

Materials ScienceTrivalent NanobodySpike ProteinEngineeringNanotechnology +8

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

M. Schuller, G.J. Correy, Stefan Gahbauer, +50

Science Advances

EngineeringNsp3 MacrodomainMolecular BiologyViral Structural ProteinVirus Structure +14

Structural basis of unidirectional export of lipopolysaccharide to the cell surface

Tristan W. Owens, Rebecca J. Taylor, Karanbir S. Pahil, +4

Nature

Lipid PreparationProteinlipid InteractionBiochemistryGlycobiologyCell Surface +4

The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport

Janine M. May, Tristan W. Owens, Michael D. Mandler, +8

Journal of the American Chemical Society

Antimicrobial Resistance GeneAntimicrobial SusceptibilityHealth SciencesAntibioticsBiochemistry +12

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)<i>P</i>2 between distinct membrane pools

Nathaniel Calloway, Tristan W. Owens, Kathryn Corwith, +3

Journal of Cell Science

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Meghna Gupta, Caleigh M. Azumaya, Michelle Moritz, +76

Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport

Michael D. Mandler, Vadim Baidin, James Lee, +3

Journal of the American Chemical Society

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

M. Schuller, G.J. Correy, Stefan Gahbauer, +49

Substrate Preferences Establish the Order of Cell Wall Assembly in <i>Staphylococcus aureus</i>

Kaitlin Schaefer, Tristan W. Owens, Daniel Kahne, +1

Journal of the American Chemical Society

Protein AssemblyBacteriologyGlycobiologyMolecular BiologyBacterial Pathogens +19