Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.

Takahisa Imamura, Robert N. Pike, Jan Potempa, +1

Journal of Clinical Investigation

ImmunologyVascular Permeability EnhancementOral MicrobiologyPharmacotherapyOxidative Stress +16

Proteolysis of Human Monocyte CD14 by Cysteine Proteinases (Gingipains) from <i>Porphyromonas gingivalis</i> Leading to Lipopolysaccharide Hyporesponsiveness

Shunji Sugawara, Eiji Nemoto, Hiroyuki Tada, +3

The Journal of Immunology

Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from <i>Staphylococcus aureus </i>

Takahisa Imamura, Sumio Tanase, Grzegorz Szmyd, +3

The Journal of Experimental Medicine

A Novel Mechanism for Bradykinin Production at Inflammatory Sites

Andrzej Kozik, Robert B. Moore, Jan Potempa, +3

Journal of Biological Chemistry

ImmunologyCytoskeletonTissue KallikreinChemical BiologyTryptase/elastase Mixture +17

Activation of Blood Coagulation Factor X by Arginine-specific Cysteine Proteinases (Gingipain-Rs) from Porphyromonas gingivalis

Takahisa Imamura, Jan Potempa, Sumio Tanase, +1

Journal of Biological Chemistry

Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens.

Takahisa Imamura, Adam Dubin, William R. Moore, +2

PubMed

Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)

Hidetoshi Nitta, Yoshihiro Wada, Yoshiaki Kawano, +12

Clinical Cancer Research

Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites

Takahisa Imamura, Jan Potempa, Robert N. Pike, +3

Infection and Immunity

ImmunologyOral MicrobiologyInflammationBioanalysisPlasma Clot Formation +16

Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis

Takahisa Imamura, Jan Potempa, Robert N. Pike, +1

Infection and Immunity

Protein SecretionImmunologyVascular Permeability EnhancementCytoskeletonCellular Physiology +21

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide–Generating Agents Improves the Therapeutic Effects of Nanomedicines

Waliul Islam, Jun Fang, Takahisa Imamura, +4

Molecular Cancer Therapeutics