Similarity network fusion for aggregating data types on a genomic scale

Bo Wang, Aziz M. Mezlini, Feyyaz Demir, +5

Nature Methods

EngineeringSimilarity MeasureGeneticsGenomicsGene Recognition +16

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

Benjamin J. Raphael, Ralph H. Hruban, Andrew J. Aguirre, +260

Cancer Cell

Functional GenomicsPancreatic CancerPathologyCancer GenomicsPancreatic Ductal Adenocarcinoma +4

iReckon: Simultaneous isoform discovery and abundance estimation from RNA-seq data

Aziz M. Mezlini, Eric Smith, Marc Fiume, +7

Genome Research

EngineeringGeneticsNovel IsoformsTranscriptomics TechnologyGenomics +19

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

Solveig K. Sieberts, Fan Zhu, Eli A. Stahl, +97

Nature Communications

ImmunologyGenetic EpidemiologyImmune-related Gene PolymorphismGenetic MedicineInflammatory Arthritis +17

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Ayush Noori, Aziz M. Mezlini, Bradley T. Hyman, +2

Neurobiology of Disease

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease

Alberto Serrano‐Pozo, Zhaozhi Li, Ayush Noori, +7

Nature Aging

Neurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseAgingApoe Alleles +11

Incorporating networks in a probabilistic graphical model to find drivers for complex human diseases

Aziz M. Mezlini, Anna Goldenberg

PLoS Computational Biology

EngineeringSystem MedicineInteraction NetworkBayesian FrameworkNetwork Analysis +24

Identifying Cancer Specific Functionally Relevant miRNAs from Gene Expression and miRNA-to-Gene Networks Using Regularized Regression

Aziz M. Mezlini, Bo Wang, Amit G. Deshwar, +2

PLoS ONE

EngineeringMachine LearningGene Expression ProfilingElastic Net RegularizationTumor Biology +16

Neoadjuvant endocrine therapy with or without palbociclib in low-risk patients: a phase III randomized double-blind SAFIA trial

Khalid Alsaleh, Heba Al Zahwahry, A. Bounedjar, +25

Journal of Cancer Research and Clinical Oncology

Endocrine OncologyOncologyNeoadjuvant Endocrine TherapyPhase IiiPharmacology +6

Finding associations in a heterogeneous setting: statistical test for aberration enrichment

Aziz M. Mezlini, Sudeshna Das, Anna Goldenberg

Genome Medicine