TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Francesca Cignarella, Fabia Filipello, Bryan Bollman, +17

Acta Neuropathologica

TREM2 regulates microglial cell activation in response to demyelination in vivo

Claudia Cantoni, Bryan Bollman, Danilo Licastro, +10

Acta Neuropathologica

InflammationNeurodegenerative DiseasesMedicineImmunologyBrain-immune Interaction +5

The <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Yuetiva Deming, Fabia Filipello, Francesca Cignarella, +33

Science Translational Medicine

Alterations of host-gut microbiome interactions in multiple sclerosis

Claudia Cantoni, Qingqi Lin, Yair Dorsett, +25

EBioMedicine

CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions

Enrique Álvarez, Laura Piccio, Robert Mikesell, +4

Multiple Sclerosis Journal

ImmunodeficienciesImmunologyImmune RegulationPathologyNeuroinflammation +17

B Cell Antigen Presentation Is Sufficient To Drive Neuroinflammation in an Animal Model of Multiple Sclerosis

Chelsea R. Parker Harp, Angela S. Archambault, Julia Sim, +7

The Journal of Immunology

Inflammatory DemyelinationImmunologyImmune RegulationCd4 T Cell ResponsesImmunotherapy +14

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

Laura Piccio, Claudia Cantoni, Jacob G. Henderson, +11

European Journal of Immunology

ImmunologyImmune RegulationPathologyMyelin AntigensImmune System +25

Alterations of the gut mycobiome in patients with MS

Saumya Shah, Alberto Locca, Yair Dorsett, +17

EBioMedicine

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

Suzanne E. Schindler, Carlos Cruchaga, Amulya Joseph, +15

Neurology Genetics

Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity

Gregory F. Wu, Kenneth S. Shindler, Eric J. Allenspach, +5

Journal of Autoimmunity

Immunological MemoryAutoimmune DiseaseMedicineImmunologyAntigen Processing +11