Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Ron O. Dror, Hillary F. Green, Céline Valant, +11

Nature

Molecular PharmacologyDrug TargetBiochemistryFunctional SelectivityMedicine +9

Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.

Xin-Ru Zhou-Pan, Eric Sérée, Xiaojing Zhou, +4

PubMed

Metabolomic ProfilingSecondary MetaboliteToxicological MechanismMolecular PharmacologyCytochrome P450 3A +19

Copper‐Catalyzed Preparation of γ‐Alkylidenebutenolides and Isocoumarins under Mild Palladium‐Free Conditions

Samuel Inack‐Ngi, Raphaël Rahmani, Laurent Comméiras, +5

Advanced Synthesis & Catalysis

Acid DerivativesChemical EngineeringCross-coupling ReactionDerivativesEngineering +12

Crystal structure of the M ₅ muscarinic acetylcholine receptor

Ziva Vuckovic, Patrick R. Gentry, Alice E. Berizzi, +14

Proceedings of the National Academy of Sciences

Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes

F. Fontaine, Georges de Sousa, Philip Burcham, +2

Life Sciences

Metabolomic ProfilingAnimal HepatocytesToxicological MechanismOxidative StressCytochrome P450 3A +14

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid<i>Trypanosoma brucei</i>

Lori Ferrins, Michelle Gazdik, Raphaël Rahmani, +10

Journal of Medicinal Chemistry

8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Matthew L. Dennis, Michael D. Lee, Jitendra R. Harjani, +16

Chemistry - A European Journal

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Daniel Stoessel, Cameron J. Nowell, Amy J. Jones, +9

Metabolomics

BiochemistryAfrican TrypanosomiasisMedicineMetabolomic ProfilingSphingolipid Metabolism +4

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Stephanie Russell, Raphaël Rahmani, Amy J. Jones, +22

Journal of Medicinal Chemistry

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Lori Ferrins, Raphaël Rahmani, Melissa L. Sykes, +13

European Journal of Medicinal Chemistry

Medicinal ChemistryHuman African TrypanosomiasisAntiparasitic AgentParasitic ProtozoaAfrican Trypanosomiasis +6