Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

Benjamin Faustin, Lydia Lartigue, Jean‐Marie Bruey, +7

Molecular Cell

InflammationSignal TransductionSignaling PathwayCell DeathInflammasome +6

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

David Furman, Junlei Chang, Lydia Lartigue, +17

Nature Medicine

InflammationAutoimmune DiseaseImmunologyChronic InflammationPathology +6

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

Ryuji Yamaguchi, Lydia Lartigue, Guy Perkins, +6

Molecular Cell

Signal TransductionMolecular PhysiologyBh3 DependentSignaling PathwayNatural Sciences +9

The permeability transition pore signals apoptosis by directing Bax translocation and multimerization

Francesca De Giorgi, Lydia Lartigue, Manuel Bauer, +6

The FASEB Journal

ApoptosisCell DeathMolecular BiologyCytoskeletonPtp Opening Signals +20

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

Lydia Lartigue, Yulia Kushnareva, Youngmo Seong, +3

Molecular Biology of the Cell

MitophagyBiochemistryMitochondrial FunctionMedicineNatural Sciences +11

Electrical coupling and plasticity of the mitochondrial network

Francesca De Giorgi, Lydia Lartigue, François Ichas

Cell Calcium

Mitochondrial FunctionMolecular BiologyElectrophysiologyElectrical CouplingMedicine +1

Mechanism of Bcl-2 and Bcl-X _L inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

Benjamin Faustin, Ya Chen, Dayong Zhai, +4

Proceedings of the National Academy of Sciences

Inhibit Nlrp1Molecular RegulationApoptosisImmunologyInnate Immune System +23

Identification and super-resolution imaging of ligand-activated receptor dimers in live cells

Pascale Winckler, Lydia Lartigue, Grégory Giannone, +5

Scientific Reports

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

Jorge Vera, Lydia Lartigue, Suzanne Vigneron, +7

eLife

Cancer BiologyTumor BiologySignaling PathwayCell RegulationPp2a Activity +15

Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2

Christelle Harly, Stephen Paul Joyce, Charlotte Domblides, +22

Science Immunology

Human γδ TcrImmunologyImmune RegulationImmunologic MechanismAmpk-dependent Metabolic Tumor +17