IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Kevin C. Conlon, E. Lake Potter, Stefania Pittaluga, +15

Clinical Cancer Research

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma

Masao Nakagawa, Arthur L. Shaffer, Michele Ceribelli, +24

Cancer Cell

Transcriptional RegulationT-regulatory CellImmunologyAdult T-cell Leukemia-lymphomaMedicine +2

Sp1 Binds Two Sites in the CD11c Promoter In Vivo Specifically in Myeloid Cells and Cooperates with AP1 to Activate Transcription

John D. Noti, Bruce C. Reinemann, Michael Petrus

Molecular and Cellular Biology

Molecular BiologyCd11c PromoterSp1 BindingSplicing VariantMyeloid Neoplasia +15

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia

Meili Zhang, Lesley A. Mathews Griner, Damien Duveau, +11

Proceedings of the National Academy of Sciences

Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T‐cell malignancies

Liyanage P. Perera, Meili Zhang, Masao Nakagawa, +5

American Journal of Hematology

Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

Jing Chen, Yong Zhang, Michael Petrus, +13

Proceedings of the National Academy of Sciences

Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

Thomas A. Waldmann, Kevin C. Conlon, Donn M. Stewart, +13

Blood

Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

John C. Morris, John E. Janik, Jeffrey D. White, +10

Proceedings of the National Academy of Sciences

Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin’s lymphoma

Meili Zhang, Kelli M. Wilson, Michael Petrus, +6

Proceedings of the National Academy of Sciences

ImmunologyPathologyBiological TherapyPharmacotherapyImmunotherapy +19

Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

Sigrid Dubois, Miloš D. Miljković, Thomas A. Fleisher, +9

Journal for ImmunoTherapy of Cancer