Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Ryan G. Lim, Lisa Salazar, Daniel K. Wilton, +48

Nature Neuroscience

NeuroregenerationDevelopmental BiologyMolecular NeuroscienceDevelopmental AlterationsMedicine +11

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

Joshua Crapser, Joseph Ochaba, Neelakshi Soni, +3

Brain

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Joseph Ochaba, Alex Mas Monteys, Jacqueline G. O’Rourke, +4

Neuron

Knockout MouseNeurodegenerative DiseasesDevelopmental BiologyMolecular NeuroscienceHuntington ’ +8

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

Jack C. Reidling, Aroa Relaño-Ginés, Sandra M. Holley, +23

Stem Cell Reports

Stem Cell-based TherapiesCellular NeurobiologySocial SciencesNeuroregenerationNeurology +16

Impaired Intestinal Vitamin B1 (Thiamin) Uptake in Thiamin Transporter-2–Deficient Mice

Jack C. Reidling, Nils Lambrecht, Mohammad A. Kassir, +1

Gastroenterology

Vitamin NutritionNutritionNutrient PhysiologyPhysiologyPharmacology +11

Expression and promoter analysis of SLC19A2 in the human intestine

Jack C. Reidling, Veedamali S. Subramanian, Pradeep K. Dudeja, +1

Biochimica et Biophysica Acta (BBA) - Biomembranes

Promoter AnalysisMolecular PhysiologyProtein ExpressionGene RegulationPathology +6

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

Ryan G. Lim, Osama Al‐Dalahmah, Jie Wu, +26

Nature Communications

Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization

Isabella Sanchez, Thai B. Nguyen, Whitney England, +15

Journal of Clinical Investigation

N-Glycosylation is required for Na+-dependent vitamin C transporter functionality

Veedamali S. Subramanian, Jonathan S. Marchant, Jack C. Reidling, +1

Biochemical and Biophysical Research Communications

Molecular PhysiologyBiochemistryMedicineMembrane TransportNatural Sciences +6

Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells

Jack C. Reidling, Veedamali S. Subramanian, Tamara Dahhan, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

Cellular PhysiologyOxidative StressAscorbic AcidHepatotoxicityCell Signaling +16