Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Nikhil M. Urs, Steven M. Gee, Thomas F. Pack, +11

Proceedings of the National Academy of Sciences

Psychotropic MedicationSynaptic TransmissionNeurotransmitterPsychopharmacologyCortical Hypodopaminergia +17

Noncanonical scaffolding of G _αi and β-arrestin by G protein–coupled receptors

Jeffrey S. Smith, Thomas F. Pack, Asuka Inoue, +15

Science

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

Sean M. Peterson, Thomas F. Pack, Angela D. Wilkins, +5

Proceedings of the National Academy of Sciences

Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity

Jeffrey S. Smith, Haley Hanseler, John Welle, +12

Journal of Clinical and Translational Science

DecontaminationVirologyVarious Decontamination ProceduresInfectious Respiratory DiseaseMask Degradation +10

C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways

Jeffrey S. Smith, Priya Alagesan, Nimit K. Desai, +5

Molecular Pharmacology

The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation

Thomas F. Pack, Margo Orlen, Caroline Ray, +2

Journal of Biological Chemistry

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorFunctional SelectivityNeurotransmitter +8

Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity

Jeffrey S. Smith, Haley Hanseler, John Welle, +12

VaccinationDecontaminationCovid-19 PandemicImmunologyVirology +12

Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions

Samuel J. Rose, Thomas F. Pack, Sean M. Peterson, +3

Neuropsychopharmacology

Molecular PharmacologyDopamine-dependent FunctionsG Protein-coupled ReceptorMedicineNeuroscience +4

Multiple Modes of α7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents

Can Peng, Matthew R. Kimbrell, Chengju Tian, +4

Molecular Pharmacology

Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness

Joshua C. Snyder, Lauren K. Rochelle, Caroline Ray, +7

Journal of Biological Chemistry